Active prospective studies

PROton Versus Photon Therapy for Esophageal Cancer - a Trimodality Strategy

The PROTECT trial (NCT05055648) is testing the hypothesis that proton (PT) -enabled radiation dose reductions to sensitive, normal tissues will result in lower rates of treatment-related pulmonary complications in esophageal cancer compared to standard photon therapy (XT). The trial is actively recruiting in Trento with participation of Gastroenterology, Medical Oncology, Surgery and both radiotherapy units in Trento (photon and proton radiotherapy)

TOVEL Trial / STOPSTORM

Proton Radiosurgery for the Treatment of Malignant Ventricular Tachyarrhythmias

The TOVEL trial (NCT06769451) evaluates the toxicity and efficacy of proton radiotherapy in the acute phase (during the first 30 days of the procedure) and at 3, 6 and 12 months in patients with malignant ventricular tachyarrhythmias. The trial is actively recruiting in Trento with participation of cardiology and proton therapy. With TOVEL, APSS also contribute to the European STOPSTORM project.

SACRO Trial

SAcral Chordoma: a Randomized & Observational study on surgery versus definitive radiation therapy in primary localized disease (SACRO)

The SACRO trial (NCT02986516) attempts a prospective comparison between the 2 treatment modalities, surgery and definitive radiotherapy, for primary localized sacral chordoma. The trial is actively recruiting in Trento, directly or as collaborators of other recruiting centers.

Pediatric Trials

The center is actively participating, as collaborator of recruiting oncology centers, in a number of pediatric oncologic therapy optimization studies